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March 29, 2024

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As the months and years wear on in the COVID-19 pandemic crisis, it is becoming increasingly evident that both with the respiratory infection caused by SARS-CoV-2 coronavirus and with repeated and frequent systemic administrations of COVID-19 vaccines that, the human body is being loaded with coronavirus Spike protein.

In the medical literature, terms such as “Spike protein disease,” “Spikopathy,” and “Spike prion-like illness” are appearing. With a size of 180–200 kDa, the Spike protein consists of an extracellular N-terminus, a transmembrane domain anchored in the viral membrane, and a short intracellular C-terminal segment.1

The Spike protein normally exists in a metastable, prefusion conformation; once the virus engages the human ACE-2 receptor, extensive structural rearrangement of the Spike protein occurs, allowing the virus to fuse with the host cell membrane. The spikes are coated with polysaccharide molecules to camouflage them, evading surveillance of the host immune system during entry into the body.

The total length of the Spike protein is 1273 amino acids and consists of a signal peptide (amino acids 1–13) located at the N-terminus, which is cleaved, the S1 subunit (14–685 residues), and the S2 subunit (686–1273 residues); the last two regions are responsible for receptor binding and membrane fusion, respectively. In the S1 subunit, there is an N-terminal domain (14–305 residues) and a receptor-binding domain (319–541 residues); the fusion peptide (FP) (788–806 residues), heptapeptide repeat sequence 1 (912–984 residues), heptapeptide repeat sequence 2 (1163–1213 residues), transmembrane domain (1213–1237 residues), and cytoplasm domain (1237–1273 residues) comprise the S2 subunit.

Spike protein trimers visually form a characteristic bulbous, crown-like halo surrounding the viral particle structure of the SARS-CoV-2 trimeric S protein has been determined by cryo-electron microscopy at the atomic level to be dynamic and take on conformations at different phases of viral action. Far less is described in the literature on the Spike protein that is produced from mRNA and adenoviral DNA vaccines, which billions of persons have taken into their bodies across the globe.

Based upon what is known, the COVID-19 vaccine-produced Spike protein carries with it at least as much pathogenicity, if not more than the Spike protein that is on the surface of an intact SARS-CoV-2 virion. 

In this weeks Report, Dr Jean-François Lesgards, Laboratoire Sondes Moléculaires en Biologie et Stress Oxydant, Institut de Chimie Radicalaire, Aix Marseille Université, Marseille, France, does a deep dive on this protein that is now apart of so many lives in this post-COVID-19 vaccine world.2

So let’s get real, let’s get loud; on America Out Loud Talk Radio, this is The McCullough Report!

The McCullough Report: Sat/Sun 2 PM ET Encore 7 PM – Internationally recognized Dr. Peter A. McCullough, known for his iconic views on the state of medical truth in America and around the globe, pierces through the thin veil of mainstream media stories that skirt the significant issues and provide no tractable basis for durable insight. Listen on iHeart Radio, our world-class media player, or our free apps on AppleAndroid, or AlexaEach episode goes to major podcast networks early in the week and can be heard on-demand anywhere in the world.

References:

1 https://www.nature.com/articles/s41401-020-0485-4#:~:text=With%20a%20size%20of%20180,%2Dterminal%20segment%20%5B11%5D.
2 https://www.linkedin.com/in/jflesgards/?originalSubdomain=fr

  • Dr. Peter McCullough

    Dr. McCullough is an internist, cardiologist, and epidemiologist managing the cardiovascular complications of both the viral infection and the injuries developing after the COVID-19 vaccine in Dallas, TX, USA. Since the outset of the pandemic, Dr. McCullough has been a leader in the medical response to the COVID-19 disaster and has published “Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection,” the first synthesis of sequenced multidrug treatment of ambulatory patients infected with SARS-CoV-2 in the American Journal of Medicine and subsequently updated in Reviews in Cardiovascular Medicine. He has dozens of peer-reviewed publications on the infection and has extensively commented on the medical response to the COVID-19 crisis in TheHill, America Out Loud, NewsMax, One America News, Victory Channel, NTD, and FOX NEWS Channel. Dr. McCullough has testified on pandemic response multiple times in the US Senate, Texas Senate Committee on Health and Human Services, Arizona Senate, Colorado General Assembly, New Hampshire Senate, Pennsylvania Senate, and South Carolina Senate. On December 7, 2022, Dr. McCullough co-moderated a Senate Panel and concluded that all COVID-19 vaccines should be removed from the market for excess mortality. Dr. McCullough has reviewed thousands of reports, participated in scientific congresses, group discussions, and press releases, and has been considered among the world's top experts on COVID-19.

MANY VOICES, ONE FREEDOM: UNITED IN THE 1ST AMENDMENT

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GreenLanternMD
GreenLanternMD
1 year ago

Simply put, the vaccine is made of the part of the Covid virus that is the problem, but, unlike previous vaccines, doesn’t go way and causes ongoing problems like a chronic infection would.

Dave
Dave
1 year ago

Please put that in layman terms. 90% of normal people can’t understand this.

Documentedtruth
Documentedtruth
1 year ago

The American people and world needs to hold accountable the pushers of this vax poison, and the media that silence the truth on how simple this virus is to treat. Dr. Vladimir Zelenko saved millions of lives with his simple over the counter protocol that worked flawlessly. Millions were murdered by the government mandated death treatment protocols. Black Americans were lied to by the US Government on treatment protocols that resulted in the 10,000s of deaths, and that is why you are seeing the covid19 being downplayed now.

stpaulchuck
stpaulchuck
Reply to  Documentedtruth
1 year ago

we’ve been taking Quercetin and vitamins all along

clady
clady
1 year ago

so where is this article or podcast?

Lou
Lou
1 year ago

If the virus has never been isolated, as reported by so many, how can anyone presume to have such specifics. Are you simply passing along the Chinese model information?

susan price
susan price
1 year ago

Good article.

stpaulchuck
stpaulchuck
1 year ago

this is why we held out. The Novavax is the first real vaccine. It shoots some spikes with no ability to replicate into you. The body does what it does with any real vaccine and you are as protected as your natural immunity allows. While the mRNA junk sends in genes that encode for creating spike proteins that migrate all over the body and keep making the spikes. None of the “boosters” or other injections stop that.

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