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December 3, 2021

December 3, 2021

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Oral and Nasal Virucidal Therapy in Prevention and Treatment of COVID-19

by | Sep 24, 2021 |

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The push for prophylaxis and treatment of SARS-CoV-2 oropharyngeal infection starts in the nose and mouth. A randomized trial by Choudhury et al. from Bangladesh has been overlooked by US public agencies but not the early treatment organizations around the world.

In this prospective randomized controlled trial, n=606 high-risk subjects with incipient COVID-19 were randomized to 1% povidone-iodine (betadine) solution as a rinse was used for a target of every four hours versus lukewarm water for four weeks. By day 7, the rates of positive nasal PCR for SARS-CoV-2 were 2.64% versus 70.3%, p<0.0001. The hospitalization rates and oxygen support and death rates were 3.3% vs. 20.8% and 0.66% vs. 5.61% (84% and 88% reductions, respectively) for the povidone-iodine vs. lukewarm water groups, p<0.0001. 

We know to apply these concepts to pre-exposure prophylaxis twice a day and postexposure four times a day. During active early treatment, it is reasonable to aim for every four hours with the goal of reducing viral load and reinoculation. If there is iodine sensitivity or intolerance, then dilute hydrogen peroxide, dilute sodium hypochlorite, followed by Listerine or Scope mouthwash can be used in the mouth only with attention to not swallowing. For the nose, saline rinses, nasal ozone, and colloidal silver hydrosol can be used, but the randomized trial support is not present. 

More good news came from the State of Uttar Pradesh in India, which declared victory over the Delta outbreak with the broad use of ivermectin. This is important as more partially and fully vaccinated Americans are spreading and contracting COVID-19; early treatment should be given in an unbiased and non-discriminatory manner. 

Fillmore and colleagues from the Veterans Administration have published that 24% of hospitalized COVID-19 Americans are vaccinated. This is consistent with CDC data from the COVID-Net collaborative from 13 states wherein the month of June 23% were partially or fully vaccinated. Thus, the vaccinated are progressively contributing to the burden of hospitalizations as the vaccines fail to control the Delta variant. 

The September 17, 2021, FDA meeting on Pfizer’s proposed COVID-19 booster, which is another injection of 30 mcg of mRNA coded for the extinct wild-type Spike protein, failed to approve the broad use of boosters. Presentations by Drs Jessica Rose, David Wiseman, Peter Doshi, and Paul Alexander collectively made the case that across the broad range of age groupings, that a vaccine recipient was more likely to die after the injection than taking the risk of contracting COVID-19 and dying of the infection. 

Shockingly, the vaccine stakeholders did not have a refutation of this analysis. This is consistent with a recently published analysis from Kostoff and coworkers. The nonfatal vaccine injuries came to attention recently with a claim made by Nicki Minaj of a relative who developed orchitis after the COVID-19 vaccination.

Because the vaccines cause circulating SARS-CoV-2 Spike protein damage to the body, it is not far-fetched since Chen and researchers from Wuhan reported earlier in the pandemic that 22.5% of infected men referred for scrotal ultrasound indeed met a radiographic definition of orchitis. For young persons such as Ms. Minaj, natural immunity is common.

In a summary from Jennifer Block in the British Medical Journal, there are now 20 supportive studies demonstrating the immunity after SARS-CoV-2 respiratory infection is robust, complete, and durable and cannot be improved upon with vaccination.  

We have a wonderful show with guests Dr. Richard Urso from Houston, TX, who gives us his insights on the crisis. Finally, an early innovator and COVID-19 specialist, Ivette Lozano, from Dallas, TX, gives us an update on obesity, diabetes, hyperglycemia, and weight loss during COVID-19 illness.  

So let’s get real, let’s get loud, on America Out Loud Talk Radio, this is The McCullough Report!

The McCullough Report: Sat/Sun 2 PM ET Encore 7 PM – Internationally recognized Dr. Peter A. McCullough, known for his iconic views on the state of medical truth in America and around the globe, pierces through the thin veil of mainstream media stories that skirt the major issues and provide no tractable basis for durable insight. Listen on iHeart Radio, our world-class media player, or our free apps on AppleAndroid, or Alexa.


Dr. Peter McCullough

Dr. Peter McCullough is an internist, cardiologist, epidemiologist, in academic medical practice in Dallas, Texas, USA. He maintains ABIM certification in internal medicine and cardiovascular diseases. He manages common infectious diseases as well as the cardiovascular complications of both the viral infection and the injuries developing after the COVID-19 vaccine.

Since the outset of the pandemic, Dr. McCullough has been a leader in the medical response to the COVID-19 disaster and has published "Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection," the first synthesis of sequenced multidrug treatment of ambulatory patients infected with SARS-CoV-2 in the American Journal of Medicine and subsequently updated in Reviews in Cardiovascular Medicine.

He has 51 peer-reviewed publications on the infection and has commented extensively on the medical response to the COVID-19 crisis in TheHill and on FOX NEWS Channel.

On November 19, 2020, Dr. McCullough testified in the US Senate Committee on Homeland Security and Governmental Affairs and throughout 2021 in the Texas Senate Committee on Health and Human Services, Colorado General Assembly, New Hampshire Senate, and South Carolina Senate concerning many aspects of the pandemic response. Dr. McCullough has had 18 months of dedicated academic and clinical efforts in combating the SARS-CoV-2 virus and in doing so, has reviewed thousands of reports, participated in scientific congresses, group discussions, press releases, and has been considered among the world's experts on COVID-19.

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Mike A
Mike A
2 months ago

This might be silly, but another hygene thing I wonder is pillowcases. Your face is likely on it 7-9 hours a day. Seems prime for harboring and re-exposure if you are carrying any viral particles? Keep a few clean ones around, and swap out every few days. It may even help out that mypillow guy! Is there a way to PCR test a pillowcases?!

2 months ago

The player does not work for this site please make it easier and correct it

Nerina Bellinger
Nerina Bellinger
Reply to  pete
1 month ago

Pete – I believe the podcast from 9/27 “Keeping Clean Where it Counts” is the same as this one (based on the guest names). Great podcast chock full of info!

2 months ago

This podcast isn’t on the app or site it’s been scrubbed even the alternative media are censoring this now? WTF

2 months ago

Randomised trial not support nasal virucidal approaches for prophylaxis are you serious?




Oh no that’s lies as shown with the links nasal virucidal prophylaxis doesn’t just prevent infection entirely by up to 80% it prevents symptomatic infection by greater than 50% and that’s just nasal not oral as well!

Hmm oh cmon you don’t see

Last edited 2 months ago by Bill
1 month ago

Can you use a diluted Iodine in a NediPod?

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