Risks of Vaccines for Those Recovered from COVID-19 – Krammer, Raw & Mathioudakis

by | Sep 12, 2021 |

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There is recent research on the fact that the COVID-19 vaccine is dangerous for those who have already had COVID-19 and have recovered with inferred robust, complete, and durable immunity. These patients were excluded from the FDA-approved clinical trials performed by Pfizer, Moderna, and J&J. From these trials, the safety profile was unknown when the products for approved for Emergency Use Authorization in 2020. There has been no study demonstrating clinical benefit with COVID-19 vaccination in those who have well documented or even suspected prior COVID-19 illness.

A medical study of United Kingdom healthcare workers who had already had COVID-19 and then received the vaccine found that they suffered higher rates of side effects than the average population. Rachel K. Raw, et al., Previous COVID-19 infection but not Long-COVID-19 is associated with increased adverse events following BNT162b2/Pfizer vaccination, medRxiv (preprint), (last visited June 21, 2021).

Previous COVID-19 infection but not Long-COVID is associated with increased adverse events following BNT162b2/Pfizer vaccination

The test group experienced more moderate to severe symptoms than the study group that did not previously have COVID-19.

The symptoms included fever, fatigue, myalgia-arthralgia, and lymphadenopathy. Id. Raw found that in 974 individuals who received the BNT162b2/Pfizer vaccine, those with a prior history of SARS-CoV-2 or those who had positive antibodies at baseline had a higher rate of vaccine reactions than those who were COVID-19 naive.


Mathioudakis et al. reported that in 2020 patients who underwent vaccination with either mRNA-based or vector-based COVID-19 vaccines, COVID-19-recovered patients who were needlessly vaccinated had higher rates of vaccine reactions.


Krammer et al. reported on 231 volunteers for COVID-19 vaccination, 83 of whom had positive SARS-CoV-2 antibodies at the time of immunization. The authors found: “Vaccine recipients with preexisting immunity experience systemic side effects with a significantly higher frequency than antibody naïve vaccines (e.g., fatigue, headache, chills, fever, muscle or joint pains, in order of decreasing frequency, P < 0.001 for all listed symptoms, Fisher’s exact test, two-sided).”


Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine

Natural Immunity to COVID-19

To my knowledge, there are no studies that demonstrate the clinical benefit of COVID-19 vaccination in COVID-19 survivors or those with suspected COVID-19 illness or subclinical disease who have laboratory evidence of prior infection.

It is my opinion that SARS-CoV-2 causes an infection in humans that results in robust, complete, and durable immunity, and is superior to vaccine immunity which by comparison has demonstrated massive failure including over 10,000 well-documented vaccine failure cases as reported by the CDC before tracking was stopped on May 31, 2021.

There are no studies demonstrating the clinical benefit of COVID-19 vaccination in COVID-19 survivors, and there are three studies demonstrating harm in such individuals. Thus, it is my opinion that the COVID-19 vaccination is contraindicated in COVID-19 survivors, many of whom may be in the student population.

Multiple laboratory studies conducted by highly respected U.S. and European academic research groups have reported that convalescent mildly or severely infected COVID-19 patients who are unvaccinated can have greater virus-neutralizing immunity—especially more versatile, long-enduring T- cell immunity—relative to vaccinated individuals who were never infected.

See Athina Kilpeläinen, et al., Highly functional Cellular Immunity in SARS-CoV-2 Non- Seroconvertors is associated with immune protection, bioRxiv (preprint),

Highly functional Cellular Immunity in SARS-CoV-2 Non-Seroconvertors is associated with immune protection

(last visited June 26, 2021); Tongcui Ma, et al., Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence, bioRxiv (preprint),

Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence

(last visited June 26, 2021); Claudia Gonzalez, et al., Live virus neutralisation testing in convalescent patients and subjects vaccinated against 19A, 20B, 20I/501Y.V1 and 20H/501Y.V2 isolates of SARS-CoV-2, medRxiv (pre-print), (last visited June 21, 2021); Carmen Camara, et al. Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals, bioRxiv (preprint),

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naïve and COVID-19 recovered individuals

(last visited June 26, 2021); Ellie N. Ivanova, et al., Discrete immune response signature to SARS-CoV-2 mRNA vaccination versus infection, medRxiv (preprint),

Discrete immune response signature to SARS-CoV-2 mRNA vaccination versus infection

(last visited June 26, 2021); Catherine J. Reynolds, et al., Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose, (preprint),

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

(last visited June 21, 2021); Yair Goldberg, et al., Protection of previous SARS-CoV-2 infection is similar to that of BNT162b2 vaccine protection.

Cleveland Clinic studied their employees for the effects of natural immunity in unvaccinated people. Nabin K. Shrestha, Patrick C. Burke, Amy S. Nowacki, Paul Terpeluk, Steven M. Gordon, Necessity of COVID-19 vaccination in previously infected individuals, medRxiv (preprint),

Necessity of COVID-19 vaccination in previously infected individuals

(last visited June 21, 2021). They found zero SARS-CoV-2 reinfections during a 5-month follow-up among n=1359 infected employees who were naturally immune remained unvaccinated and concluded such persons are “unlikely to benefit from COVID-19 vaccination.”Among those who were vaccinated, unlike the naturally immune, there were vaccine failure or breakthrough cases of COVID-19.

An analysis by Murchu et al. demonstrated in 615,777 individuals, which included well-documented COVID-19 as well as subclinical infections with positive serologies, there was a negligible incidence (<1%) of COVID-19 over the long term. Murchu found no evidence of waning immunity over time, suggesting no possibility that future vaccination would be indicated for any reason.

Quantifying the risk of SARS-CoV-2 reinfection over time

A recently published article in Nature reported that prior infection induces long-lived bone marrow plasma cells, which means the antibodies to prevent reinfection of COVID-19 are long-lasting. Jackson S. Turner et al. SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans (May 24, 2021).

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

Dr. Peter McCullough

Dr. McCullough is an internist, cardiologist, and epidemiologist managing the cardiovascular complications of both the viral infection and the injuries developing after the COVID-19 vaccine in Dallas, TX, USA.

Since the outset of the pandemic, Dr. McCullough has been a leader in the medical response to the COVID-19 disaster and has published “Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection,” the first synthesis of sequenced multidrug treatment of ambulatory patients infected with SARS-CoV-2 in the American Journal of Medicine and subsequently updated in Reviews in Cardiovascular Medicine. He has 56 peer-reviewed publications on the infection and has extensively commented on the medical response to the COVID-19 crisis in TheHill, America Out Loud, and FOX NEWS Channel.

On November 19, 2020, Dr. McCullough testified in the US Senate Committee on Homeland Security and Governmental Affairs, in 2021-2022, the Texas Senate Committee on Health and Human Services, Colorado General Assembly, New Hampshire Senate, Pennsylvania Senate, and South Carolina Senate concerning many aspects of the pandemic response. On January 24, 2022, Dr. McCullough co-moderated and testified in the US Senate Panel “COVID-19: A Second Opinion” chaired by Senator Ron Johnson. Dr. McCullough has reviewed thousands of reports, participated in scientific congresses, group discussions, and press releases, and has been considered among the world's top experts on COVID-19.

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Brenda
Brenda
1 year ago

Thank you, thank you, thank you! We SO need more mainstream info on natural immunity for awareness. One of my best friends is Covid recovered and does not want the vaccine as she trusts her own natural immunity. Now she’s at the inevitable crossroads of having to decide whether to “roll the dice” and get vaccinated due to the mandates. These are horrific circumstances for so many people.

Now I hear there are even more restrictions being placed on doctors and the narrative they must follow or face dire consequences. What a tragedy. It’s doctors like yourself and the other select few, that people like myself ( who have decided to now take their health into their own hands) who are so appreciative of all of your hard work.

Keep up the fight!

Best regards,
Brenda

Ely
Ely
1 year ago

Dear Dr. McCullough, the recent Maccabi (ultra-pro-vax Israeli HMO) supported study: “Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections” spoke of the superiority of natural immunity, giving it wide coverage worldwide (particularly among anti-vaccine advocates – classic propaganda tactics). Yet the bottom line of the conclusion is: “Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.” I have no expertise in this field, but thought you should know.
https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1

Terry
Terry
Reply to  Ely
1 year ago

Though that “additional protection” is true. the numbers are so tiny that it’s numerically insignificant.

Ruth Donnell
Ruth Donnell
Reply to  Ely
11 months ago

Dear Doctor McCullough, I am a register nurse and contracted Covid from a patient after given the wrong mask! on Jan 5 2021 my test was positive ! I was off work with COVID until Feb 1,2021 ! On 8/12/2021 I got the Pfizer vaccine because if the mandate! The next day I was SOB, had a sore throat, headache! The list goes on ! I have more doctor bills than I had in my life! I’m a healthy person with occasional asthma spring and summer! These reactions caused a rash like a sun burn on my left arm where I got the shot! Then it move to my chest but was more like hives , then the next day the rash went to my right lower leg as a large circle and itched so bad! I hacked up this nasty big sputum with blood specks all over in it! My doctor would not analyze it. I developed a swelling left leg that felt like a fracture! Doppler were negative for a DVT! Then petechiae but platelets we’re normal! She tested me for lupusa d it was negative! The immunologist I went to was very argumentative and handed me an article on consensus about the vaccine risk versus benefits and he said I didn’t have reactions because it was not a anaphylactic reaction! Can you help me please. No one will admit that the vaccine was harmful to me!

Andrea
Andrea
1 year ago

Do you have a list of all the studies that show natural immunity is sufficient and that they do not need a vaccine. I am trying to help inform people. I have been searching all over and there are things here and there . I would love a list. Do you have one compiled or can you send me to a site that has one. I have looked at the links above and listen to all your podcasts. Thank you Dr. C!!

Miller
Miller
11 months ago

Please help me understand….I see this at the bottom of the BioRXiV reprints that some of the above research articles above are opening up in is supported by Chan Zuckerberg Initiative. Question is are the studies in the BioRxIV sites funded by Zuckerberg or is this a reprinting site that always readers to access the articles for no cost? Seeing as how they sensor FakeBook I want to make sure these studies are unbias. I see some articles claim no conflicts of interest. Thanks

Jason Datray
Jason Datray
9 months ago

where can i go to get a vaccine medical exemption?

Marilyn
Marilyn
1 year ago

My sister is a long-haul COVID survivor(since March 2020) (main comorbidity is being overworked at age 63 and a type A+ personality) who had a pacemaker installed to regulate heart rate (which went very low when hiking). Due to the pressure of her daughter who would not allow her to see the grandchildren without the jab, she recently (August 2021) took Jab#1 and has had very bad reactions (brain fog, kidney issue, “funky” nasal scent, fatigue) for 2 weeks.
What does this study say about the jab and long-haulers?

Fred Grube
Fred Grube
Reply to  Marilyn
1 year ago

I’m not a doctor, so I’m just repeating things I think I’ve heard. It seems like in general though vaccines should be avoided while the patient is sick. And since the immunity of recovered covid patients is robust, complete, and durable, it would seem therefore seem vaccination would not be advised.

And you might ask about Fluvoxamine. It seems like it can penetrate the blood brain barrier and also has some anti inflammatory properties, so maybe it would help her brain fog.

Reba Shadwell
Reba Shadwell
10 months ago

Do you have remedies for side effects from the vaccine such as a break out on the face. Is zeolite safe to use?

Jan Medved
Jan Medved
10 months ago

So if the vaccine is dangerous for those who have already had COVID-19, does that also mean that the booster shots are dangerous for those who have been “fully vaccinated”?

Norma Mayhew
Norma Mayhew
9 months ago

Dr. McCullough, I am worried about my 24 year old son. He had Covid-19 a year ago and he thinks he had it in December of 2019 also. He still has antibodies and therefore didn’t take the jab. He began having some heart palpitations, heart racing and skipping beats, shortness of breath, and dizziness last month. These symptoms seemed to begin right after his girlfriend took her first jab. Is it possible she shed on him, causing heart problems? This also happened to me. I started Aspirin and the symptoms went away. Can shedding cause myocarditis or other heart problems?

Sean
Sean
9 months ago

Thank you for all you do. Great Joe Rogan interview!

Lorraine Pettit
Lorraine Pettit
8 months ago

What are the longer term side effects after booster vaccine

Ruth Pearson Smith
Ruth Pearson Smith
8 months ago

My 32-year old granddaughter says she has COVID-19 again. The first time was over a year ago. She hasn’t gotten any innoculations at all and she had positive tests both times. She has a history of asthma, chronic bronchitis and a pulmonary embolism pre-COVID, so I was really concerned the first time – she was very sick and bedridden for several days. This time she’s not so sick but quarantined. I heard that there were not confirmed cases of repeat COVID-19. Is there another way to confirm her second case (or not)?

Maria S
Maria S
8 months ago

Hi Dr. Could you please offer me some advice on a dear friend? She had cancer of the tissue/cells of the breast stage 4 a few years back and is currently in remission. She has had both vaccination shots but now has Covid. She has not taken her Booster but I feel will want to when she recovers. What should she do to advise herself on the next step? What good literature can I direct her to please. I presuming her system will have a certain amount of vulnerability. Thank you so much. Also regarding cancer, my cousin took his second vax in August and was diagnosed a couple of weeks later with a very rare type of cancer. Is there somebody/ ANYbody (doctor) in the States you can put me in touch with please. Once again thank you so much for all the work you are doing, Maria

Greg
Greg
11 months ago

Doc,

I’m not sure if you actually read the Raw, et al., study you posted in this article to support your position – because it certainly does not support your position. It found that the healthcare workers who had covid antibodies experienced more severe side effects from the Pfizer vaccine at a rate of 56% compared to the non-anitbody study population’s 47%. So roughly half experienced severe side effects compared to… roughly half. Wow. Also, this is entirely expected! When a person already has antibodies it leads to a stronger immune response – this is why most people are experiencing more severe side effects with their second dose of the vaccine. I don’t know why I have to explain basic immunology to a doctor. Either your motives or your grasp of the science is highly questionable. People, stop drinking this man’s koolaid!

cdsdz
cdsdz
Reply to  Greg
10 months ago

At least he has known credentials…unlike yourself.

Randy
Randy
Reply to  cdsdz
10 months ago

Address any of the points made and don’t attack the person who made it: rhetoric 101 my guy

Jan Medved
Jan Medved
Reply to  Randy
10 months ago

When it comes to credentials, I find testimonies more credible than credentials – anybody can get credentials these days. That said, Dr. McCullough can produce hundreds of testimonies from people that he has cured from covid. How many testimonies can Greg or you produce? Please post here.

Jan Medved
Jan Medved
Reply to  Greg
10 months ago

Well, if we do the math slightly differently, the increase in side effects was 20%. That looks like a signal to me 🙂

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